Aclara Biosciences

Mountain View, CA

IPO (2000)

Biochip company that developed microfluidic lab-on-a-chip technology with applications for genetic analysis, high-throughput drug screening and clinical diagnostics.

ArgoMed

Cary, NC

Company developed a proprietary, water-induced thermotherapy device and technique to address the non-surgical treatment of benign prostatic hyperplasia (BPH). BPH is a condition that afflicts the majority of men over 60, causing adverse changes in urinary voiding patterns. ArgoMed's initial product received FDA market approval in 1999. Assets acquired by Circon in 2002.

BaroSense

Menlo Park, CA

BaroSense focuses on the research and development of innovative, minimally invasive medical devices for the treatment of obesity - the largest global chronic disease in adults.

BioSyntech

Laval, Quebec

TSX V: BSY

BioSyntech is a medical device company that specializes in the development, manufacturing and commercialization of advanced biotherapeutic thermogels for regenerative medicine (tissue repair) and therapeutic delivery.

CardioDx

Palo Alto, CA

CardioDx is a cardiovascular molecular diagnostics company developing tools to assist cardiologists in the diagnosis of cardiovascular disease. Its lead test, Corus-CADx, is a gene expression algorithm-based blood test for the detection of significant atherosclerotic coronary artery disease in patients with stable chest pain.

EBM Solutions¹

Nashville, TN

Acquired by HealthGate Data Corp. in 2003

Evidence-based medical solutions provider that partnered high-quality health and medical information with ongoing monitoring and analysis of healthcare organizations' online initiatives. Its evidence-based clinical guidelines are backed by independent medical review support through affiliations with Duke University Medical Center, Emory University School of Medicine, Oregon Health and Science University, and Vanderbilt University Medical Center.

Emerald BioAgriculture²

Lansing, MI

Emerald is a bioagriculture company developing, manufacturing and marketing biological and biochemical agents to improve crop yields and quality, combat disease and fight pests.

FlowCardia

Sunnyvale, CA

FlowCardia is a medical device company commercializing products for the treatment of chronic total occlusions (CTOs) of coronary and peripheral arteries. Utilizing a technology known as high-frequency mechanical recanalization, the company's CROSSER™ System safely and quickly breaks up CTOs allowing subsequent stent placement or balloon angioplasty and avoiding the trauma of cardiac surgery. FlowCardia's products are marketed throughout much of the United States.

Gentis

Wayne, PA

Gentis is a biomaterials and orthopedics company that has developed and is testing a breakthrough, non-fusion technology for treatment of spinal disc disease. Its lead product, DiscCell, is a radio-opaque implant designed to restore normal biomechanical function of a degenerated or surgically treated intervertebral disc by augmenting or replacing the worn-out gel-like tissue at its center (the nucleus pulposus).

Genstruct

Cambridge, MA

Genstruct is focused on the application of computational systems biology to drug discovery and development. The company is developing disease-specific mechanistic models that are used to discover the mechanisms underlying disease, drug action, and drug efficacy. Pappas Ventures originally invested in Incellico, Inc., which was acquired by Genstruct in July 2003.

LipoScience

Raleigh, NC

LipoScience is a diagnostic company utilizing nuclear magnetic resonance (NMR) spectroscopy to measure the size and quantity of lipoprotein particles in blood. The company's NMR LipoProfile® blood test is intended to provide a better indication of the risk of developing cardiovascular heart disease compared with standard cholesterol tests that measure 'good' and 'bad' cholesterol. The company currently markets and sells the NMR LipoProfile test to physicians, other healthcare professionals, diagnostic laboratories and clinical research clients.

NuVasive

San Diego, CA

Nasdaq: NUVA

IPO (2004)

Medical device company that designs, manufactures and markets minimally invasive spine surgery systems. Its FDA-approved system allows the surgeon to perform common open spine operations through small incisions with a proprietary, easy-to-use guidance system.

Optherion

New Haven, CT

Optherion is an early-stage biotechnology company that is developing therapeutics and diagnostic tools for age-related macular degeneration (AMD) and orphan renal diseases strongly influenced by components of the alternative complement system. Optherion's technologies are based on recent genetic discoveries linking certain genes to these disorders.

Plexigen

Cary, NC

Company developing an innovative, proprietary 3-D biochip to significantly enhance the capacity, efficiency, accuracy and automation of gene screening. The technology was originally developed at North Carolina State University.

Sensys Medical

Chandler, AZ

Sensys is developing a non-invasive blood glucose monitor that uses near infrared diffuse reflectance spectroscopy. Once cleared by the Food and Drug Administration, the technology will provide a painless method to collect data for proactive use in controlling diabetes.

TyRx

Monmouth Junction, NJ

TyRx is a medical device company developing a range of drug-eluting implantable devices based on proprietary tyrosine polymer technology licensed from Rutgers University. The company's lead product is AIGIS-Rx™, an antibiotic-eluting mesh envelope into which pacemakers and defibrillators can be inserted prior to surgical implantation, thereby reducing the risk of post-procedure infection.